Abstract
Due to its topical irritant effect on gastric mucosa naproxen is an ideal candidate for encapsulation in pH sensitive drug delivery systems such as alginate– chitosan microparticles. [...]
Highlights
Due to its topical irritant effect on gastric mucosa naproxen is an ideal candidate for encapsulation in pH sensitive drug delivery systems such as alginate– chitosan microparticles
In this study we aimed to investigate the feasibility of these carriers for oral delivery of naproxen, and to establish the kinetic mechanisms of naproxen release from microparticles under conditions simulating gastrointestinal environment
ANOVA analysis revealed that all investigated factors have statistically significant influence on drug release from microparticles (p
Summary
Due to its topical irritant effect on gastric mucosa naproxen is an ideal candidate for encapsulation in pH sensitive drug delivery systems such as alginate– chitosan microparticles. 1 Faculty of Pharmacy, Belgrade University, Belgrade, Serbia 2 DCP Hemigal, Leskovac, Serbia In this study we aimed to investigate the feasibility of these carriers for oral delivery of naproxen, and to establish the kinetic mechanisms of naproxen release from microparticles under conditions simulating gastrointestinal environment.
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