Abstract
Plant protection strategies have been proven to be the most promising approach on selection of protease inhibitors. Protease inhibition and PLA2 activity of white and violet varieties of Calotropis gigantea L., has been studied. Comparative protease inhibition studies on white and violet varieties have shown small variation in protease inhibition. In trypsin inhibition, white variety has not shown inhibition but the violet variety has shown the inhibition at 10 μl concentration. In Protease K inhibition, white variety has not shown inhibition but the violet variety has shown the inhibition at 10 μl and 5 μl concentrations respectively. In Chymotrypsin inhibition, both white and violet varieties have not shown any protease inhibition. The plant has also exhibited PLA2 inhibition activity in blood agar containing egg yolk. Protein interaction network profile has shown interactions with circulatory, neural and immune system components that can modulate and simulate the mechanism in the system approach.
Highlights
Plant cells contain different types of proteases essential for cellular activities and regulatory processes [1]
The function of proteases is repressed by molecules like Protease inhibitors, permitted the functions of the cellular processes like antigen production and the degradation of membrane or regulatory proteins [2]
Results of previous research showed that Naja naja cobra venom contains several proteins and peptides with enzymatic and non-enzymatic activities that belong to different groups including phospholipases A2 (PLA2), cardiotoxins and neurotoxins [15,16,17]
Summary
Plant cells contain different types of proteases essential for cellular activities and regulatory processes [1]. The function of proteases is repressed by molecules like Protease inhibitors, permitted the functions of the cellular processes like antigen production and the degradation of membrane or regulatory proteins [2]. Several natural products showing protease inhibitors are proteins that are important inferences for diagnosis and therapy [3]. Proteases that are harmful to the cells can be inhibited by protease inhibitors This can lead in protecting the protein of interest from degradation [7]. Results of previous research showed that Naja naja cobra venom contains several proteins and peptides with enzymatic and non-enzymatic activities that belong to different groups including phospholipases A2 (PLA2), cardiotoxins and neurotoxins [15,16,17]. To evaluate the protein activity, leaves of pink and white varieties has been collected and tested for protease inhibition and anti-venom activity
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
