Abstract
Male rats were divided into six groups of five rats each. Rats were injected subcutaneously with different concentrations of heptachlor for 2 weeks. Heptachlor at all doses significantly suppressed plasma testosterone levels ( P < 0.05). Plasma luteinizing hormone (LH) ( P < 0.01) and cortisol ( P < 0.02) levels were significantly elevated in heptachlor-treated rats as compared to corn oil–treated controls. LH and testosterone levels showed strong correlation ( r = 0.69, P < 0.05). The testes in rats treated with 25 mg/kg body weight of heptachlor showed some pathological changes. We conclude that heptachlor causes adverse effects on several male reproductive parameters in rats.
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