Abstract
Croton campestris A., popularly known as “Velame do campo” (Euphorbiaceae), is a shrub originating from Brazil, mainly present in the Southeast and Northeast regions. The objective of this study was to evaluate the antibacterial activity of the ethanol extract (EECC), hexane (HFEECC) and dichloromethane fractions (DFEECC), obtained from the ethanol extract of Croton campestris A. leaves. Antibacterial and modulating activity (on bacterial resistance) was determined by micro dilution method to identify the MIC (Minimum Inhibitory Concentration). In the antibacterial activity tests the fractions showed a MIC of ≥ 1024 µg/mL (where ≤ 128 µg/mL for MIC is considered clinically relevant). In regards to modulation of bacterial resistance, all products showed synergism when combined with antibiotic against bacterial strains. It was observed that all products potentiated the antibiotic action of all antibiotics assayed against all bacterial strains. The results indicate that the extracts and fractions obtained from Croton campestris leaves could represent an alternative source of natural products capable of modifying and interfering with bacterial resistance to aminoglycosides.
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