Abstract
An in vitro set up has been designed to study the hydraulic water permeability of hollow fiber dialysers for forward and reverse ultrafiltration flow (UF). The measurements are done using new samples and dialysers with a deposited protein layer. The ultrafiltration coefficient KUP (ml/h.mmHg) is derived from volumetrical flow measurements and transmembrane pressure (TMP) measured with fluid filled pressure transducers. The tests are performed using reverse osmose (RO) water or bicarbonate dialysate at room temperature. The protein layer on the membrane is induced in vivo or in vitro by circulating human plasma through the dialysers during 20 minutes. TMP is corrected for colloid oncotic pressure. Three samples of dialysers (Fresenius F6, F8, F60 and F80) have been evaluated. KUP is almost independent of TMP up to 600mmHg (low flux) and 60mmHg (high flux) for forward and reverse flow. Using dialysate instead of RO water decreases the permeability of the membrane (30% in F6 and 17% in F60 and F80). A protein layer on the membrane decreases KUP with 21–26% (in vitro) and 15% (in vivo) in low flux and 53–68% (in vitro) in high flux dialysers. Backfiltration renders a 75% lower KUP for F80.TableFor the usual TMP range, KUP can be considered insensitive to TMP with forward and reverse flow. Because of a lower backfiltration coefficient, the risk of pyrogenic reactions by non-pure dialysate could be overestimated.
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