Abstract
The effects of furosemide on the in vitro performances of isolated prestored (24-hour storage in Collins solution) and control unstored canine kidneys were studied on the Nizet pump oxygenator. Prestorage reduced RBF, GFR, Na reabsorption rate and PAH extraction, while it increased free water clearance and K excretion rate. In prestored kidneys, the addition of furosemide to perfusing blood did not improve the hemodynamic parameters and did not influence PAH transport despite its usual effects on Na, K and water excretion. Moreover, in unstoredkidneys, furosemide somewhat decreased RBF and GFR.
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