Abstract
In vitro parameters of cell-mediated immunity in human neonates were assessed by determination of cord blood monocyte migration and production of the lymphokine, monocyte chemotactic factor. Cell-mediated immunity to streptokinase-streptodornase, as assessed by monocyte chemotactic factor production, was not transferred from the mother to the newborn infant. There were no differences in the responses of cord monocytes to monocyte chemotactic factor produced by 18 paired maternal and cord cell cultures in response to the mitogen, PHA. These studies do not support the thesis that impaired cell-mediated immunity of human neonates is due to a reduced functional activity of monocytes.
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