Abstract
The interactions of copper(II) complexes of kanamycin A with oxidation-susceptible biomolecules: 2′-deoxyguanosine, plasmid DNA and yeast tRNA Phe were studied in both the presence and absence of hydrogen peroxide. The mixture of complex with H 2O 2 was found to be an efficient oxidant, converting dG to its 8-oxo derivative, generating strand breaks in plasmid DNA and multiple cleavages in tRNA Phe. Some of these reactions may play a role in toxic effects of aminoglycoside antibiotics. These complexes were screened for their antibacterial activity. The microbiological studies undertaken to compare the bactericidal action of kanamycin A alone and complexed with copper(II) ions in both neutral and oxidative environment revealed that the enhancement of bactericidal action by Cu(II) was not statistically significant.
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