Abstract
In this paper, we presented a comprehensive and complete study of the biological behavior of the bone forming cells, osteoblasts, on the graded nano-biphasic calcium-phosphate/Ti coatings of different compositions by investigating bone cell proliferation, bone cell viability, markers for bone cell differentiation and key genes that encode for known proteins which are important for de novo extracellular matrix and osteoid production. We prepared the gradient nano hydroxyapatite and titanium nanoparticles (nanoTi) composite coating on Ti-6Al-4V implants. Due to the size effects of nano-Ti, this process could be used to sinter nano HA/nanoTi composite coating at low temperature. The gradient coating with different concentration of HA could be prepared by controlling the composition of the nanoparticles, and the composition of nanoHA and beta-tricalcium phosphate in the coating could be varied by controlling the laser power. The coating was characterized with XRD and SEM, and exhibited excellent biocompatibility as well as bioactivity to UMR-106 cells.
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