Abstract
1. Cephalic ganglia of the locust Locusta migratoria L. were cultured in the presence of l-DOPA and inhibitors of dopa decarboxylase or dopamine β hydroxylase. 2. The addition of l-DOPA to the culture medium resulted in a marked increase of m-octopamine, following higher levels of dopamine. 3. l-DOPA produced an increase of m-tyramine. 4. RO 44602 considerably reduced the levels of p and m-octopamines, m-tyramine, dopamine and noradrenaline while fusaric acid reduced only those of p and m-octopamines, m-tyramine and noradrenaline. 5. Though not normally found in the locust nervous system, m-octopamine appears to be closely related to catecholamines and to be produced via their biosynthesizing enzymes through a hypothetical dehydroxylation step.
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