Abstract
The aim of the current study was to evaluate the potential mutagenicity of aluminium oxide nanomaterials (NMs) (Al 2O 3-30 nm and Al 2O 3-40 nm). Characterization of the NMs was done before the initiation of the study. The mutagenicity of the NMs was studied by the Ames test with Salmonella typhimurium TA100, TA1535, TA98, TA97a and TA102 strains, in the presence and absence of the S9 mixture. Based on a preliminary cytotoxicity study conducted on the strains, different concentrations of Al 2O 3-30 nm, Al 2O 3-40 nm and Al 2O 3-bulk were selected. At all the concentrations tested, Al 2O 3-30 nm and Al 2O 3-40 nm did not significantly increase the number of revertant colonies compared to the Al 2O 3-bulk and control with or without S9 mixture. Our findings suggest that Al 2O 3 NMs were devoid of any size and concentration dependent mutagenicity compared to the Al 2O 3-bulk and control.
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