Abstract
The influence of serum and protamine on the in vitro effectiveness of some preservatives has been studied. The products tested were formaldehyde, benzalkonium chloride, esters of parahydroxybenzoïc acid, benzoic and sorbic acids. Serum only strongly depleted the activity of benzalkonium chloride. In the case of protamine, this basic protein markedly enhanced the bactericidal effect of benzoic and sorbic acids and allowed a reduction in the concentration by a factor of four while still maintaining the same bactericidal power on Pseudomonas aeruginosa.
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