Abstract
Biological apatite is ion-doped and provides an active pool for the exchange with foreign impurity ions. In this work, an in vitro model of hydrated metastable octacalcium phosphate (OCP) crystals was established to mimetically investigate the distinct exchange of trivalent and divalent cations (Fe3+ and Sr2+) with biological apatite. Fe3+ significantly promoted the collapses of OCP crystals and the formation of amorphous sol-like ferric phosphates, while Sr2+ facilitated the epitaxial growth and stability of OCP crystals. The involvement of Ca2+ maintained the crystalline integrity and inhibited the ion exchange within OCP crystals. This in vitro model would lay the foundation for the further investigation of the metabolism of biological apatite.
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