Abstract
This study consisted of developing a dressing loaded with silver (Ag) and ibuprofen (IBU) that provides a dual therapy, antibacterial and antalgic, intended for infected painful wounds. Therefore, non-woven polyethyleneterephtalate (PET) textiles nonwovens were pre-treated by cyclodextrin crosslinked with citric acid by a pad/dry/cure process. Then, textiles were impregnated in silver solution followed by a thermal treatment and were then coated by Layer-by-Layer (L-b-L) deposition of a polyelectrolyte multilayer (PEM) system consisting of anionic water-soluble poly(betacyclodextrin citrate) (PCD) and cationic chitosan. Finally, ibuprofen lysinate (IBU-L) was loaded on the PEM coating. We demonstrated the complexation of IBU with native βCD and PCD by phase solubility diagram and 1H NMR. PEM system allowed complete IBU-L release in 6 h in PBS pH 7.4 batch (USP IV). On the other hand, microbiological tests demonstrated that loaded silver induced bacterial reduction of 4 Log10 against S. aureus and E. coli and tests revealed that ibuprofen lysinate loading did not interfere with the antibacterial properties of the dressing.
Highlights
Chronic wounds represent a major public health problem
Leg ulcers, burns or bedsores present an infectious risk, causing excessive inflammation that delays the healing process associated with severe pain and affect psychologic state of patients
The objective of this work was to benefit from the polyelectrolyte multilayer (PEM) coating as a protective layer that would reduce silver diffusion in the wound without losing its antibacterial activity
Summary
Chronic wounds represent a major public health problem. It is estimated that, in developed countries, 1 to 2% of the population will suffer a chronic wound during their lifetime [1]. Leg ulcers, burns or bedsores present an infectious risk, causing excessive inflammation that delays the healing process associated with severe pain and affect psychologic state of patients. An option to treating infected wounds is the use of technical dressings to provide specific therapies. There is a wide range of dressings. They consist of different biomaterials and are sometimes combined with active substances to provide specific therapies depending on the etiology of the wound. Among these dressings, silverbased dressings are widely used to treat wounds that are infected or at risk of infection
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