Abstract
1. Liver postmitochondrial supernatant preparations of calf, clearnose skate, and nurse shark were able to metabolize the fungal toxin aflatoxin B 1 to various metabolites. 2. Calf liver produced aflatoxin M 1 and Q 1 as the major chloroform soluble metabolites, with small amounts of aflatoxicol formed during incubation. 3. Liver preparations of the elasmobranchs, however, produced aflatoxicol as the major chloroform soluble metabolite with no other metabolite being detected. 4. The water soluble metabolite profiles for the three species were also quite different with the tris diol adduct being produced to a much greater extent in calf liver preparations. 5. Aflatoxicol production by the elasmobranch liver homogenates was reversible with the skate reconverting a large amount (30%) of aflatoxicol to AFB 1 The nurse shark, however, appeared to convert a portion of aflatoxicol to an unknown metabolite more polar than AFB 1. 6. Calf liver DNA bound approximately 3 × more 3H-AFB 1 than shark liver DNA.
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