Abstract
The metabolism of nornuciferine and seven of its derivatives by rat, rabbit, and guinea pig liver microsomes was studied. Nornuciferine was found as a metabolite of the N-alkylated analogs. A sensitive method for analyzing nornuciferine was developed based on reverse TLC fluorimetry. By using this method, relative N-dealkylation rates were studied with guinea pig microsomes. The conversion of nornuciferine to the oxoaporphine, lysicamine, was observed photolytically and metabolically with rat and rabbit microsomes. Chromatographic and spectral analyses of lysicamine are discussed.
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