Abstract
DNA-dependent RNA polymerase activity was measured in whole cell lysates of blastocysts recovered from the uteri of implanting and delayed-implanting mice. It was found that implanting blastocysts contained more activity than those from females with delayed implantation. The results of mixing experiments demonstrated that activity in the two types of embryos was not strictly additive and indicated that the delayed-implanting blastocysts contained an inhibitor of RNA polymerase. It is not known if the observed inhibitory activity is responsible for the metabolic dormancy associated with delayed implantation in vivo .
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