Abstract
Aims: To evaluate the diagnostic validity of an in vitro assay for indoleamine 2,3 dioxygenase (IDO) activity as indicator for biological alterations that are associated with depressive symptomatologies. Study Design: Retrospective evaluation of a medical database. Place and Duration of Study:Institute for Medical Diagnostics, Berlin, between April and July 2013. Methodology: We compared values forIDO invitro, a so far unpublished assay for IDO activity thatmeasures tryptophan degradation in peripheral blood monocytic cell (PBMC), with blood levels of tryptophan and tumor necrosis factor alpha (TNF -alpha). Values were derived from a clinical database comprising 441 patients who had received IDO in vitro,
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