Abstract
The oocyte is a unique cell in the human body, not only in its special structure and function, but also in undergoing meiosis. Meiotic progression in the oocyte is defi ned as oocyte maturation from reinitiation of the first meiotic division to metaphase-II (M-II), at the same time, accompanying cytoplasmic maturation to prepare the oocyte for subsequent fertilization and early embryonic development successfully (1). In vivo meiotic resumption of oocyte is initiated in response to the pre-ovulatory surge of luteinizing hormone (LH). LH surge triggers oocyte maturation from germinal vesicle (GV) stage to M-II stage. Practically for infertility treatment with in vitro fertilization (IVF) technology, the patients are given human chorionic gonadotropin (HCG) to induce the completion of oocyte meiosis in the follicles to retrieve M-II oocytes after 36 h of HCG injection. Without HCG injection in IVF treatment, most oocytes retrieved will be at immature GV stage.
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