Abstract
Erythrocyte 2, 3-DPG content has a marked effect on the oxyhemoglobin dissociation curve and is known to decrease in ACD stored blood. This study revealed the effect of various steroids on the level of 2, 3-DPG. Hydrocortisone sodium succinate and methylprednisolone sodium succinate were found to increase the levels of 2, 3-DPG in 3, 10, and 13 day old ACD stored blood during incubation. Hydrocortisone sodium succinate was more effective than methylprednisolone sodium succinate in increasing the level of 2, 3-DPG. In three day old blood the increased 2, 3-DPG approached the lower limits of normal values.
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