Abstract
The marked activity of 2,4-diamino-5-p-chlorophenyl-6-ethyl-pyrimidine or pyrimethamine (Daraprim) against toxoplasmosis in mice has been reported by Eyles and Coleman (1952), independently by Summers (1953), and has been confirmed by Trevino, Varela and Palencia (1953), and by Beverley and Fry (1957). The purpose of the present report is to describe the minimal effective concentration of pyrimethamine that causes inhibition and death of proliferating toxoplasmas growing in tissue cultures of monkey kidney cells and embryonic mouse mince and to present certain experimental data relative to the mode of action of pyrimethamine against Toxoplasma gondii in a tissue culture system.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
