Abstract
The present study was aimed to explore the potential of Musa acuminata var G9 leaves (banana leaves, BL) as a wound healing agent and to formulate a topical delivery system for delivering the same. BL was collected, authenticated and the leaf components were extracted by microwave-assisted extraction (MAE) using three individual solvents. Phytochemical screening of three extracts led to the selection of aqueous extract which was further subjected to by GCMS analysis. MTT assay of aqueous BL extract exhibited cytocompatibility even at higher concentrations (150 mg/mL showed 85.45%). Antibacterial studies using agar disc diffusion method revealed more susceptibility of S. aureus in comparison to E. coli for the aqueous extract. For topical application, four creams (F1-F4) were developed and characterised. Further, scratch wound healing potential of 25 mg/mL and 50 mg/mL of aqueous extract in F4 formulation was compared with marketed and control formulations using L929 cell lines which exhibited better cell migration of 25 mg/mL extract in 24 h with wound area of 44.46 ± 3.34 % compared to marketed 32.41 ± 1.63 % and control 9.38 ± 1.76 %. Thus the study indicates the potential of aqueous BL extract as a wound healing agent which can be further explored.
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