Abstract
ABSTRACTLithium salts are used in the treatment of mania and as prophylaxis against manic depressive disorder. The aim of these studies was the in vitro investigation of the effect of lithium on phospholipids of human erythrocyte membranes. Erythrocytes were treated with lithium for 1 h. Phospholipids phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylocholine (PC) were separated from erythrocyte ghosts and determined by HPLC. Blood samples from healthy adults were investigated. A very strong decrease in PC content in erythrocyte membranes due to lithium in vitro treatment was found, as well as a statistically significant increase in PI content.
Highlights
Lithium salts are used in the treatment of mania and as prophylaxis against manic depressive disorder (Goodwin and Jamison 1990)
The erythrocytes were incubated at 37◦C for 1 h with 10 mM lithium carbonate in the phosphate buffer-1
The results clearly indicate the statistically significant decrease in PC content in erythrocytes due to lithium in vitro treatment
Summary
Lithium salts are used in the treatment of mania and as prophylaxis against manic depressive disorder (Goodwin and Jamison 1990). It is dosed in concentrations below 2 mM (Romano et al 1995). A long period of treatment with lithium causes lesions to the gastroenteric tube, the nervous system, and kidneys. The therapeutic activity of lithium is supposed to be caused by lithium inhibition of inositol phosphatases, especially the inositol monophosphatase (Manji et al 1995).
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