Abstract
Many disorders, including cancer and malaria, could be targeted via the pentose phosphate pathway (PPP),whose products are key in biosynthetic reactions incells. The goal of this study was to find new PPP inhibitors. The inhibition effects of malononitrile derivatives on Glucose 6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were analyzed through invitro experiments. Besides, molecular docking studies were performed to predict the interactions having role in inhibition of compounds. K i constants of derivatives were found between 4.24±0.46-69.63±7.75 µM for G6PD and 1.91±0.12-95.07±11.08 µM for 6PGD. Derivatives indicated non-competitive inhibition on both enzymes except forcompound 4. The findings of the molecular docking studies revealed that free-binding energy estimations agreed with invitro data. The structure of these malononitrile derivatives may guide for drug discovery in targeting the PPP.
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