Abstract
The antimicrobial potential of cranberry hydro alcoholic extracts (CrE) was evaluated against Escherichia coli isolated from women with urinary tract infection (UTI). CrE was diluted based on the percentage of proanthocyanidins (PACs) in extract powder for final concentrations: 1.26%; 2.52%; 3.35%, 5.03% and 10.06%. CrE antimicrobial potential was evaluated by disk and well diffusion assays, and by in vitro direct action against E. coli. Antibacterial action was observed for all performed tests: minimal inhibitory concentration (MIC) was 1.26% PACs per disk diffusion assay and 2.52% of PACs by well diffusion assay. The in vitro antimicrobial direct action against E. coli resulted 3.8 Log10 cycles reduction for a concentration of 5.03% of PACs. One of the isolates showed multi resistance to antibiotics. But it was also inhibited more than any of the antibiotic tested in well diffusion assay. Only for concentrations 1.26%, 2.52% and 3.45% the inhibition of Escherichia coli by cranberry extract was dose-dependent, i.e directly proportional to the concentration of PACs. The results indicate a inhibitory action high potential of CrE. However, more in vitro and in vivo analysis can be performed to fix which the best concentration of CrE capable of causing a real beneficial effect on UTI´s.
Highlights
It is estimated that around 150 million urinary tract infections (UTIs) occur worldwide each year
Research indicates that the beneficial effect of cranberry on UTIs[14] occurs by blocking adhesion of E. coli to uroepithelium and inhibit urinary infection[15]
In view of the above, this study evaluated the antimicrobial potential of cranberry hydroalcoholic extract on E. coli strains get from women with urinary infection and residents in a rural community of Santa Catarina state, Brazil
Summary
It is estimated that around 150 million urinary tract infections (UTIs) occur worldwide each year. Research indicates that the beneficial effect of cranberry on UTIs[14] occurs by blocking adhesion of E. coli to uroepithelium and inhibit urinary infection[15]. In view of the above, this study evaluated the antimicrobial potential of cranberry hydroalcoholic extract on E. coli strains get from women with urinary infection and residents in a rural community of Santa Catarina state, Brazil.
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