Abstract
The antialgal action of aqueous rue extract was investigated and, after isolation and identification of active compounds, the biological activity of related chemical compounds was also compared in order to study their structure‐activity relationship. The most active substances isolated from Ruta were identified as 5‐methoxypsoralen (5‐MOP) and 8‐methoxypsoralen (8‐MOP). These compounds were algistatic up to 5×10‐5M and their activity was species‐specific. The structure‐activity relationships of coumarin derivates as antialgal compounds evidenced an increased inhibitory activity when oxygen(s) was present on the coumarin skeleton. Methoxyl groups do not seem to be important. Among flavonoids activity increased in the following order: flavone > flavanone. For phenylpropanoids the antialgal activity was linked to the number as well as to the position of the methoxyl groups on the ring.
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