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Abstract
It has been shown that normal rat lymph node cells can be autosensitized in vitro against dissociated testis cells from the same donor animal. The present study was undertaken to demonstrate that self-responsive activated lymphocytes can revert back to quiescent small secondary lymphocytes and that immunological memory can be induced in vitro against the autoantigens. Injection of lymphoblasts raised in mixed cultures of fresh lymphocytes and autologous trypsin-dissociated testis cells can induce progressive orchitis. It was found that L.BDV secondary lymphocytes primed against autologous testis cells responded strongly when exposed to syngenic L.BDV testis cells but failed to react against allogenic Lewis testis cells thus demonstrating the immune specificity of the autosensitized secondary EAO lymphocytes. These findings combined with other data suggest that major histocompatible gene complex autoantigens are recognized in the secondary reaction. 2 degree EAO lymphocytes however were restimulated not only by syngeneic testis cells but also to an even greater extent by syngeneic lymph node cells whereas fibroblasts did not exhibit such a response. Possible explanations of the nature of the autoantigens that elicit the secondary EAO reaction are discussed. This autoimmune memory system is proposed as a model for the study of the physiological mechanisms responsible for self-tolerance at the T cell level.
Published Version
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