Abstract
Meeting abstracts Trastuzumab (Herceptin®), a humanized anti-ErbB2 antibody is a specific targeted therapy against ErbB2 positive tumors, with a history of both success and a high rate of therapy resistance. Another humanized antibody, pertuzumab (Perjeta®) inhibits ErbB2 heterodimerization.
Highlights
Trastuzumab (Herceptin®), a humanized anti-ErbB2 antibody is a specific targeted therapy against ErbB2 positive tumors, with a history of both success and a high rate of therapy resistance
Pertuzumab (Perjeta®) inhibits ErbB2 heterodimerization. While these antibodies have been developed based on the in vitro direct cellular effect of their mouse parent antibodies, there is the possibility that their in vivo mechanism of action roots rather in antibody dependent cellular cytotoxicity (ADCC) exerted by natural killer (NK) cells
Our goal was to ascertain the extent of contribution of the direct cellular effect of the antibodies and that of the in vivo evoked ADCC to tumor growth inhibition
Summary
Trastuzumab (Herceptin®), a humanized anti-ErbB2 antibody is a specific targeted therapy against ErbB2 positive tumors, with a history of both success and a high rate of therapy resistance. In vivo and microscopic analysis of tumor immunotherapy using combination of two antibodies against the same ErbB2 target While these antibodies have been developed based on the in vitro direct cellular effect of their mouse parent antibodies, there is the possibility that their in vivo mechanism of action roots rather in antibody dependent cellular cytotoxicity (ADCC) exerted by natural killer (NK) cells.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
