Abstract
Abstract Biodegradable materials are widely used in biomedical application. Blending polymers have become a promising strategy to regulate degradation rate and expand material properties. In this study, the poly(D, L-lactic acid) (PDLLA) and polyCL-lactide-co-ɛ-caprolactone) (PLcCL) blend films with different ratios were prepared by the ultrasonic spray technology and the in vitro hydrolytic degradation tests of these films were then carried out in phosphate buffered saline with 37°C and 50°C. The in vitro degradation of the blend films were investigated via mass loss, gel permeation chromatography (GPC), scanning electron microscopy (SEM). It was found that the blended film had good miscibility and uniformity through SEM tests. Besides, the 50/50 PLcCL/PDLLA film showed the slowest degradation rate at 37°C, while at 50°C, the 100 PLcCL film had the slowest degradation. This work can provide helpful suggestions for the evaluation of biodegradable polymer coating materials in degradable polymer coated stent.
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