Abstract
Objective: The study was aimed to evaluate in vitro hepatoprotective activity of yellow leaf extracts of Thespesiapopulnea.
 Methods: Hepatoprotective activity is studied by carbon tetrachloride-induced hepato-toxicity in isolated rat hepatocytes. The biochemical parameters observed in serum were serum glutamate oxaloacetate transaminase (SGOT/AST), serum glutamate pyruvate transaminase (SGPT/ALT) levels. The extracts exhibited a dose-dependent reduction in AST, ALT levels.
 Results: Methanolic extract was found to exhibit higher hepatoprotection. T. populnea extract was found to be antihepatotoxic at a concentration of 125 mcg with a significant decrease in ALT (P<0.001) and AST (P<0.0001).
 Conclusion: The results suggest that the methanolic extract has produced significant (p<0.001) hepatoprotection by decreasing the activity of serum enzymes which is comparable to that of standard drug silymarin.
Highlights
Hepatic diseases are one of the fatal diseases in the world but today plant-based preparations have a lot to do with the alleviation of hepatic diseases
Yellow leaves of Thespesiapopulnea were collected from Kozhikode, Kerala in the month of January 2018
The liver damage in Carbon tetra chloride induced hepatotoxin is mainly assessed by determining the serum enzyme levels
Summary
Hepatic diseases are one of the fatal diseases in the world but today plant-based preparations have a lot to do with the alleviation of hepatic diseases. Liver is an aerobic organ which generates reactive oxygen species that induce oxidative tissue damage. These radicals react with cell membranes and induce lipid peroxidation or cause inflammation, which may result as important pathological mediators in many clinical disorders such as heart disease, diabetes, gout and cancer. Reduction of these radicals by antioxidant molecules is crucial to the protection of cells against various disorders. Flavonoids are phenolic compounds widely distributed in plants and have been reported to exert multiple biological effects, including antioxidant and free radical scavenging abilities
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