Abstract
Dermal papilla cells (DPCs) are a source of nutrients and growth factors, which support the proliferation and growth of keratinocytes as well as promoting the induction of new hair follicles and maintenance of hair growth. The protection from reactive oxygen species (ROS) and the promotion of angiogenesis are considered two of the basal mechanisms to preserve the growth of the hair follicle. In this study, a noncrosslinked hyaluronic acid (HA) filler (HYDRO DELUXE BIO, Matex Lab S.p.A.) containing several amino acids was tested with in vitro assays on human follicle dermal papilla cells (HFDPCs). The experiments were carried out to investigate the possible protection against oxidative stress and the ability to increase the vascular endothelial growth factor (VEGF) release. The results demonstrated the restoration of cell viability against UVB-induced cytotoxicity and an increase in the VEGF secretion. These data demonstrate the capability of the product to modulate human dermal papilla cells, suggesting a future use in mesotherapy, a minimally invasive local intradermal therapy (LIT), after further clinical investigations.
Highlights
Hair is a specialized derivative structure of the skin and a defining characteristic of the human integumentary system
The cytotoxicity test is required to evaluate the effect of the tested product on cell viability and to identify the appropriate concentrations that do not cause a decrease in cell respiration exceeding 20%
The same result was obtained dissolving the product in a medium with low concentration (1%) of FBS. 40 and 80 mg/ml concentrations were tested for long-time treatment (Figure 1(b)), demonstrating the absence of cytotoxicity up to 72 h and used for the subsequent experiments
Summary
Hair is a specialized derivative structure of the skin and a defining characteristic of the human integumentary system. Dermal papilla cells (DPCs), located at the base of the hair follicle, are a specialized mesenchymal component of the hair that are very important in the morphogenesis and regeneration of hair growth. They act as a source of nutrients and growth factors, which support the proliferation and growth of keratinocytes as well as promoting the induction of new hair follicles and maintenance of hair growth [1]. VEGF is a crucial regulator of physiological angiogenesis during skin development, and its overexpression in hair follicle epithelial cells is responsible
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