Abstract
The fibrinolytic activity, effect on the fibrinolytic activity of plasmin, anticoagulant activity and anti platelet aggregation activity of a low molecular weight heparan sulfate ( LMW HS Bal ) were investigated “in vitro” on blood plasma obtained from rats and rabbits. LMW HS Bal at concentrations as low as 0.25 – 2 μg/ml prevented thrombin-induced platelet aggregation. At concentrations 25 to 50 times larger it showed no significant anticoagulant activity but a marked fibrinolytic effect. At still larger concentrations LMW HS Bal also potentiated the fibrinolytic activity of plasmin. Conversely, unfractionated heparan sulfate (UHS) at concentrations of 25 to 50 μg/ml, only showed anticoagulant activity with no fibrinolytic activity.
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