Abstract
The Sperm Chromatin Structure Assay (SCSA) determines the percentage of sperm with high levels of DNA fragmentation. Clinical studies have suggested that a DNA fragmentation index (DFI) above 27-30% results in a fair to poor fertility potential; men with an elevated DFI are at risk for taking longer to establish a natural pregnancy, requiring more routine IVF cycles to establish a pregnancy, a higher chance of spontaneous miscarriages or no pregnancy (Larson 2000; Evenson 2002). It has been suggested that the DFI for ICSI derived pregnancies is actually higher than 27-30%.
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