Abstract
OBJECTIVE: To determine whether: 1. There is a difference in IVF outcome between patients who had an SMR or a polypectomy in the year prior to IVF and those who had no prior surgery; 2. The time interval between surgery and IVF impacts outcome. DESIGN: Retrospective cohort study. MATERIALS AND METHODS: We stratified our sample into 3 groups: Those with an SMR in the prior year, those with a polypectomy, and those with no surgery. Groups were matched by age, parity, protocol, # of prior IVF cycles and mature oocytes. One-way ANOVA and Chi-square tests were used. We compared outcome between those who did IVF within 3 months of surgery and those who waited longer. Student's t-test was used. RESULTS: No significant difference in demographics, implantation (IR) or clinical pregnancy rates (PR) was seen among the 3 groups. Among those with an SMR, there was no significant difference in IR (20% vs 23%) or PR (36% vs 44%) between the two time intervals. Among those with a polypectomy, similar IR were seen between the two time intervals (23% vs 16%, p= 0.18). However, a trend towards greater PR was seen in the shorter interval group (45% vs 24%, p = 0.06).Tabled 1IVF Outcome by SurgerySMR (n=39)Polypectomy (n=54)No Surgery (n= 98)p valueAge (yrs)40.2 ± 2.940.1 ± 2.940.2 ± 0.70.9Protocol (% Luteal suppression)7474720.9# Prior IVF Cycles1.5 ± 1.91.2 ± 2.11.3 ± 1.60.8# Mature Oocytes8.82 ± 4.68.24 ± 4.47.82 ± 5.00.5IR0.22 ± 0.30.20 ± 0.30.17 ± 0.30.5PR0.41 ± 0.50.35 ± 0.50.31 ± 0.50.5M ± SD. Open table in a new tab M ± SD. CONCLUSION: IVF soon after hysteroscopic surgery does not appear to negatively affect outcome. The trend towards increased PR in those who did IVF within 3 months of their polypectomy might be due to an initial benefit of the procedure or from a residual effect of altering the endometrial environment. Further investigation of the impact of intra-uterine surgery on IVF outcome is warranted.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
