Abstract
The influence of naloxone on the peristaltic reflex of isolated segments of various parts of the guinea pig small intestine was examined. The narcotic antagonist (−)naloxone (2×10−7M), but not its stereoisomer (+)naloxone, increased the frequency of peristaltic waves in ileal segments by an average of 12%. In addition, it decreased the length and number of peristalsis-free intervals during periods of elevated intraluminal pressure. Thus, it increased over-all-peristaltic-activity by 25–60%, dependent upon intraluminal pressure.
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