Abstract
AbstractThe antiviral dn cytotoxic activity of SP‐303, a naturally occurring polyphenolic polymer (average M.W. = 2,100 daltons) isolated from a Euphorbiaceae shrub, was evaluated in tissue culture. The compound exhibited selective antiviral activity (ratio IC50/EC50 ≥10) against parainfluenza virus type 1, respiratory syncytial virus, influenza A viruses, and influenza B viruses; marginal selective antiviral activity (IC50/EC50 ratio >2 to <10) against parinfluenza virus type 3; and no selective antiviral activity (IC50/EC50 ratio ≤1) against measles virus or adenovirus type 5. Hemagglutination and other studies suggested that SP‐303 may at least partially inactivate virus by direct interaction with virus or host cell lipid membranes. © Wiley‐Liss, Inc.
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