Abstract
Abstract Enrofloxacin can be slowly delivered through polymeric systems and the addition of oil could increase the polymeric gels hydrophobicity and help the continuous release. The present work intended to develop and characterize microstructurally (XRD and FTIR) and in vitro (swelling and antimicrobial tests) the PVA hydrogels loaded with copaiba oil and Duotrill (enrofloxacin) to treat bacterial infections, as pyelonephritis, in the veterinary field. Duotrill® and oil combined diminished the gels degree of crystallinity and it was observed interaction between phases due to a new band found only in PVA hydrogels loaded with copaiba oil and Duotrill (PVA-D-O) FTIR spectrum. The samples with oil swelled less than samples without it, where copaiba oil altered the samples’ hydrophilicity. PVA-D-O presented lower weight loss and higher gel fraction than PVA, indicating the loaded material increased the gels stability. All samples containing oil and Duotrill® inhibited S. aureus.
Highlights
Pyelonephritis is a name used to describe an inflammatory process of the pelvis and renal parenchyma originated by bacterial infections all over the lower urinary tract
Duotrill and oil combined diminished the gels degree of crystallinity and there is an interaction between phases revealed by a new band found only in polyvinyl alcohol (PVA)-D-O sample’s FTIR
Duotrill and copaiba oil combined diminished the gels degree of crystallinity and there is an interaction between phases revealed by a new band found only in PVA-D-O sample’s FTIR
Summary
Pyelonephritis is a name used to describe an inflammatory process of the pelvis and renal parenchyma originated by bacterial infections all over the lower urinary tract. These bacterial infections are generally caused by aerobic bacteria, e.g. Escherichia coli and Staphylococcus sp., and rarely by species of Proteus, Streptococcus, Klebsiella and Enterobacter[1,2]. There is a wide variety of antibiotics to treat bacterial diseases in animals, specially dogs and cats. There is an increase of intoxication due to the incorrect use (overdose) of this medicine. One possible alternative to avoid poisoning is the use of drug delivery systems (DDS), e.g. hydrogels[4]
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