Abstract
Objective: The objective of the study was to in vitro evaluate of hypolipidemic effect of extracts of medicinal Dracaena cinnabari Balf. f. resin.
 Methods: About 800 g of dry powder of the resin of dracaena cinnabar was taken in a Soxhlet apparatus and subjected for sequential extraction of solvents from non-polar to polar end (hexane, benzene, diethyl ether, dichloromethane, chloroform, ethyl acetate, acetone, ethanol, methanol, and water); the extract samples were kept at 4°C for further assays. All the extracts were subjected to glucose uptake assay.
 Results: The ethanol extract showed significant (p<0.05) hypolipidemic effect by decreasing the activity of enzyme such as significant reduction in the pancreatic lipase enzyme, malic dehydrogenase enzyme, and glucose-6-phosphate dehydrogenase enzyme with IC50~13, ~13, and ~14, respectively. This results were similar to the standard drug atorvastatin with IC50~12, ~16, and ~17, respectively. Ethanol extract exhibited significant atherogenic index and percentage protection against hyperlipidemia. The potential biological activity of ethanol extract may be attributed to the highest polarity which needs further investigation.
Highlights
One of the most common vital threats for the accelerated atherosclerosis and cardiovascular diseases is hyperlipidemia [1,2]
Hypolipidemic decrease by the effect of the pancreatic lipase, malic dehydrogenase, and glucose-6-phosphate dehydrogenase enzymes The enzyme inhibition studies of the glucose-6-phosphate dehydrogenase were evaluated at different concentrations (25, 50, and 75 μM) of the resin of dragon’s blood
It was noticed that while performing the test for the enzyme inhibition of the glucose6-phosphate dehydrogenase, the other extracts showed moderate and unsignificant effects compared to the ethanol extract which showed significant hypolipidemic effect by decreasing the activity of enzyme with IC50 ~13
Summary
One of the most common vital threats for the accelerated atherosclerosis and cardiovascular diseases is hyperlipidemia [1,2]. It is considered as one of the diseases which have it is own problematic consequences and impact on the health of a human. Dragon’s blood has been found to be safe even at very high doses in human clinical trials [7]. It has so many treatment uses, but due to the bioavailability of this tree, it has no effective therapeutic molecule [8]
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