Abstract
Postoperative adhesions are one of the most important problems that the patients and surgeons face. In this study, nanofibrous mats as a novel surgical adhesion barrier were produced from polysaccharide-based polymers, hyaluronic acid, carboxymethyl cellulose and sodium alginate, via electrospinning. The produced nanofibrous mats were crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysulfosuccinimide. Furthermore, the morphology, and the in vitro degradation, cytotoxicity and cell adherence potential of the nanofibrous mats aimed to be used as adhesion barriers were evaluated and compared with a commercial adhesion barrier. After the crosslinking process, the nanofibrous structure was maintained, and the diameters of resulting nanofibers were below 300 nm. Results of the in vitro experiment showed that the nanofibrous mats have maintained their physical structures during the critical period for adhesion formation, and had non-adherent cell feature and non-cytotoxic nature required for an ideal adhesion barrier.
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