Abstract
Download options Please wait... Supplementary files Supplementary information PDF (1054K) Article information DOI https://doi.org/10.1039/C4RA04575K Article type Paper Submitted 15 May 2014 Accepted 16 Jul 2014 First published 17 Jul 2014 This article is Open Access Download Citation RSC Adv., 2014,4, 32628-32638 BibTex EndNote MEDLINE ProCite ReferenceManager RefWorks RIS Permissions Request permissions In vitro evaluation of copper-chelating properties of flavonoids M. Říha, J. Karlíčková, T. Filipský, K. Macáková, L. Rocha, P. Bovicelli, I. P. Silvestri, L. Saso, L. Jahodář, R. Hrdina and P. Mladěnka, RSC Adv., 2014, 4, 32628 DOI: 10.1039/C4RA04575K This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given. Read more about how to correctly acknowledge RSC content. Social activity Tweet Share Search articles by author Michal Říha Jana Karlíčková Tomáš Filipský Kateřina Macáková Liliana Rocha Paolo Bovicelli Ilaria Proietti Silvestri Luciano Saso Luděk Jahodář Radomír Hrdina Přemysl Mladěnka
Highlights
Flavonoids represent a large group of polyphenolic compounds which belong to plant secondary metabolites
A meticulous regulation of copper homeostasis is necessary because unbound copper ions participate in the formation of reactive oxygen species (ROS) due to the catalysis of the Fenton-like reaction which causes damage to various biological structures.[12]
In contrast to trientine which formed the same complex at all pH conditions, luteolin formed likely the complex 1 : 1 at pH 5.5 while the stoichiometry of complexes with baicalein and myricetin was on average between 1 : 1 and 1 : 2 at this pH and it could not be established with certainty from the current experiment
Summary
Flavonoids represent a large group of polyphenolic compounds which belong to plant secondary metabolites. Their ubiquity in the plant kingdom and high content especially in fruits and vegetables make them a common component of the human diet. A meticulous regulation of copper homeostasis is necessary because unbound copper ions participate in the formation of ROS due to the catalysis of the Fenton-like reaction which causes damage to various biological structures.[12] A typical example of copper homeostasis disorder is Wilson's disease, which is caused by the chronic copper overload due to a speci c genetic abnormality.[13] Despite some controversy, the disruption of copper homeostasis is involved in various pathological states including neurodegenerative diseases, tumours and acute myocardial infarction.[14,15,16,17]
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