Abstract
A series of 6-Hetero aryl-5-hexene-2, 4-diones (1a-b) and their Cu (II) complexes (1c-d) of ML2 stoichiometry were synthesized by condensation of heterocyclic aldehydes with acetyl acetone through boric anhydride mediated mechanism. Boric anhydride act by blocking the medial methylene group of acetyl acetone and provides a new pathway other than facile Knoevenagel condensation. All the final structures were assigned on the basis of IR, 1H NMR and mass spectra analysis. The test compounds were studied for short term in vitro cytotoxicity using Dalton’s Lymphoma Ascites cell lines (DLA). The compound code 1C and 1D found to show significant cytotoxic action.
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