Abstract
A new antibacterial copper (Cu)-bearing titanium alloy, Ti-6Al-4V-5Cu alloy is fabricated by introducing Cu into conventional titanium alloy. However, Cu is a double-edged sword and excessive Cu ions release may lead to biological problems. In this study, considering the potential toxicity of Cu release from Ti-6Al-4V-5Cu alloy, the cytocompatibility, hemocompatibility and electrochemical corrosion behaviour of the alloy are systematically studied. The results indicate that MC3T3-E1 cells grew well on surface of Ti-6Al-4V-5Cu alloy and the relative growth rate is higher than 75%, showing good cytocompatibility. Platelets on surface of Ti-6Al-4V-5Cu alloy are less and fully spread, and the hemolysis ratio is 0.6%, showing good hemocompatibility of the alloy. Ti-6Al-4V-5Cu alloy shows great potentials in clinical application with strong antibacterial performance, good cytocompatibility and hemocompatibility.
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