In vitro evaluation of biodegradable magnesium alloys containing micro-alloying additions of strontium, with and without zinc

Abstract

Event Abstract Back to Event In vitro evaluation of biodegradable magnesium alloys containing micro-alloying additions of strontium, with and without zinc Junlan Wang1*, Shayanti Mukherjee2*, David Nisbet2*, Nick Birbilis1* and Xiaobo Chen1* 1 Monash University, Materials Science and Engineering, Australia 2 The Australian National University, Research School of Engineering, Australia Abstract: The in vitro degradation of magnesium (Mg) alloys containing low levels of strontium (Sr, 0.05, 0.1 and 0.2 wt.%) with and without additions of zinc (Zn, 0.5 and 1.0 wt.%), was studied for potential use in orthopaedic fracture treatments. Sr-containing Mg-alloys were selected as a promising strategy to utilise the biological role of Sr through alloying, to induce accelerated bone tissue growth. The influence of controlled alloying upon degradation rate was studied via electrochemical measurements and immersion tests in minimum essential medium (MEM). Immersion testing revealed a comparable degradation rate of the alloys tested herein, indicating no detrimental effect of Sr on degradation. Cytotoxicity experiments on primary mouse osteoblasts indicated good biocompatibility and enhanced proliferation of osteoblasts for all the tested Mg alloys. Potentiodynamic polarisation testing further confirmed that low-level additions of Sr imparted a minor influence on cathodic kinetics, with a slight inhibition of anodic kinetics. In contrast, the addition of Zn as a ternary element moderated both anodic and cathodic kinetics of Mg-Sr alloys. Xiaojian Xia Keywords: Tissue Engineering, in vitro, material design, Biodegradable metal Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Metallic biomaterials and alloys Citation: Wang J, Mukherjee S, Nisbet D, Birbilis N and Chen X (2016). In vitro evaluation of biodegradable magnesium alloys containing micro-alloying additions of strontium, with and without zinc. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01355 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. * Correspondence: Dr. Junlan Wang, Monash University, Materials Science and Engineering, Melbourne, Australia, junlan.wang@monash.edu Dr. Shayanti Mukherjee, The Australian National University, Research School of Engineering, Canberra, Australia, shayanti.mukherjee@gmail.com Dr. David Nisbet, The Australian National University, Research School of Engineering, Canberra, Australia, david.nisbet@anu.edu.au Dr. Nick Birbilis, Monash University, Materials Science and Engineering, Melbourne, Australia, nick.birbilis@monash.edu Dr. Xiaobo Chen, Monash University, Materials Science and Engineering, Melbourne, Australia, xiaobo.chen@monash.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Junlan Wang Shayanti Mukherjee David Nisbet Nick Birbilis Xiaobo Chen Google Junlan Wang Shayanti Mukherjee David Nisbet Nick Birbilis Xiaobo Chen Google Scholar Junlan Wang Shayanti Mukherjee David Nisbet Nick Birbilis Xiaobo Chen PubMed Junlan Wang Shayanti Mukherjee David Nisbet Nick Birbilis Xiaobo Chen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.