Abstract
Zataria multiflora has been widely used for health promotion purpose. We have studied anticholinesterase, antioxidant and antibacterial effects of different fractions of a standard extract of Z. multiflora. Rosmarinic acid (RA) content of plant was determined by spectrophotometric method and anticholinesterase and antioxidant activity of various fractions was studied using colorimetric method and diphenylpicrylhydrazyl (DPPH) assay respectively. Minimum inhibitory concentration (MIC) of fractions against a variety of bacteria was determined by agar dilution method. Results: RA content of the plant was 2.2% (w/w). Chloroform fraction (CHF) exhibited the greatest anticholinesterase effect (94.05± 7.6%) followed by petroleum ether fraction (PEF) (88.7±5.1%). Methanolic fraction (MF) exhibited the highest DPPH inhibition (93.3± 4.1%) followed by PEF and CHF (88.7± 3.7% and 85.4± 2.5% respectively). The least MIC was due to PEF and CHF against Gram-negative and Grampositive bacteria respectively. Conclusion: These results indicated that PEF and CHF would be a good candidate for further studies.
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