Abstract
Antianthelmintic activity of successive extracts (chloroform, acetone, ethanol and aqueous) of Nauclea orientalis leaves were evaluated separately on adult Indian earthworm (Pheretima posthuma) and compared with that of albendazole. It was found that the extracts exhibited, respectively dose-dependent action and inhibition of spontaneous motility (paralysis) and death of earthworms. The results indicated that the chloroform, ethyl acetate and ethanol extracts were more potent.
Highlights
Antianthelmintic activity of successive extracts of Nauclea orientalis leaves were evaluated separately on adult Indian earthworm (Pheretima posthuma) and compared with that of albendazole
Literature review showed the presence of indole alkaloidal glycosides and nine angustinetype alkaloids in the ammoniacal extracts of leaf
The anthelmintic activity was evaluated on adult Indian earthworms, Pheritima postuma (Annelida), due to its anatomical and physiological resemblance with intestinal round worm parasites of human beings[7,8,9,10]
Summary
Antianthelmintic activity of successive extracts (chloroform, acetone, ethanol and aqueous) of Nauclea orientalis leaves were evaluated separately on adult Indian earthworm (Pheretima posthuma) and compared with that of albendazole. Considering this Nauclea orientalis has been evaluated for its anthelminthic activities. Literature review showed the presence of indole alkaloidal glycosides and nine angustinetype alkaloids in the ammoniacal extracts of leaf. The anthelminthic activity of the plant extract has not been reported in the literature.
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