In vitro electrically controlled amoxicillin release from 3D-printed chitosan/bismuth ferrite scaffolds

Abstract

The goal of this study was to design and fabricate a 3D-printed wound dressing using chitosan as a bioink, with the ability to release the antibiotic drug amoxicillin (AMX) in response to mild electrical stimulation. This was achieved through the incorporation of bismuth ferrite (BFO) nanoparticles, which have both magnetic and ferroelectric properties. The chitosan-based scaffolds containing various concentrations of BFO were analyzed using Fourier transform infrared spectroscopy, and the release of AMX from the scaffolds was evaluated in vitro under electrical stimulation. The results demonstrated that the scaffolds had a suitable structure for drug loading and release, and the release of AMX was successfully controlled by the applied electrical stimulus. The maximum tensile strength (4.97 ± 0.34 MPa) was observed at the ratio of 6% CHT/0.025% BFO scaffolds and the scaffold with 6% CHT/0.075% BFO had the maximum cell viability of (∼130%) at 168 h incubation time. This study highlights the potential of BFO to deliver therapeutic drugs from a 3D-printed chitosan scaffold in a controlled manner.