Abstract
The effects of synthetic muscimol and an extract from Amanita muscaria, containing this compound on the activity of human recombinant MAOB enzyme (hMAOB) were studied. Muscimol had statistically significant inducing effect on hMAOB at concentrations 0.25–5 μM, while A. muscaria extract did not influence the enzyme activity at all.
Highlights
Monoamine oxidase (MAO) catalyses the oxidative deamination of monoamines in the brain and peripheral tissues, regulating their levels and their biological effects
Dopamine is oxidised by both isoforms (Youdim et al 2006). Both enzymes catalyse the oxidative deamination of substrates through a FAD-dependent mechanism that releases hydrogen peroxide, ammonia and an aldehyde product (Ramsay and Albreht 2018)
The aim was to compare the effects of Amanita muscaria extract and synthetic muscimol on human recombinant MAOB enzyme activity
Summary
Monoamine oxidase (MAO) catalyses the oxidative deamination of monoamines (neurotransmitters, dietary amines, hormones and drugs) in the brain and peripheral tissues, regulating their levels and their biological effects. Unlike muscimol, is much more dangerous, causing ibotenate-induced seizures and lesions in specific brain regions, similar to Alzheimer’s disease for which it is used in animal test models (Stebelska 2013). Voynova M et al.: In vitro effects of muscimol and an extract from A. muscaria on hMAOB enzyme on the GABA-metabolizing enzyme, GABAA transaminase, and the GABAA uptake systems, which enters the brain after peripheral injection (Snodgrass 1978).
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