Abstract
Objectives: Our study aimed to examine the effects of salicylic acid on paraoxonase activity in healthy volunteers. Methods: Plasma from healthy volunteers was spiked with salicylic acid drug. The working solutions were then diluted with plasma to obtain concentrations that covered the therapeutic margin. Specimens were incubated at 25 and 37°C, and we measured PON1 activities in the presence of different drug concentrations after 1 h, 3 h, and 24 h and after one week. Results: After incubation in vitro, a significant increase of paraoxonase 1 activity according to salicylic acid concentration and incubation duration, regardless of temperature incubation was showed. This increase was marked especially after 24 h of incubation. The stimulatory effect of salicylic acid is concentration and incubation durationdependent and does not seem to be related to temperature incubation. Conclusion: The tested Salicylic acid significantly stimulated PON1 activity in a concentration dependent manner. This result shows that acetyl salicylic acid treatments have a beneficial effect dose and time dependent that may contribute to prevent atherosclerosis.
Highlights
Salicylic acid (SA) is used to prevent complications of atherosclerotic cardiovascular disease such as myocardial infarction and occlusive stroke [1]
The tested Salicylic acid significantly stimulated PON1 activity in a concentration dependent manner. This result shows that acetyl salicylic acid treatments have a beneficial effect dose and time dependent that may contribute to prevent atherosclerosis
PON1 activity in the control plasma was stable over the experiment duration
Summary
Salicylic acid (SA) is used to prevent complications of atherosclerotic cardiovascular disease such as myocardial infarction and occlusive stroke [1]. Salicylic acid treatment has been reported to result in a 32% reduction in the risk of a first myocardial infarction. This drug is used in the treatment of patients with acute coronary syndromes. Paraoxonase 1 is synthesized in the liver and is thought to be exclusively associated with high-density lipoprotein in the plasma. Paraoxonase 1, a high-density lipoprotein associated antioxidant enzyme, has been shown to protect the serum lipids from oxidation and can reduce macrophage foam cell formation and attenuates atherosclerosis development. Human serum PON1 activity was reported to be inversely related to the risk of coronary artery disease (CAD) [3]. Our study aimed to investigate the in vitro effects of salicylic acid on human plasma paraoxonase 1 activity
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