Abstract
Live and γ-irradiated-killed Brucella abortus strain 2308 increased interleukin 1 (IL-1), but not interleukin 2 (IL-2), interferon-γ (IFN-γ), or prostaglandin E 2 (PGE 2) production when incubated with normal bovine peripheral blood mononuclear cells (PBMC). Live B. abortus was more effective than killed B. abortus in stimulating IL-1 production by normal PBMC. Both live and killed B. abortus were equally effective in suppressing IL-2 and IFN-γ production by Concanavalin A-stimulated PBMC. Incubation of PBMC with the cyclo-oxygenase inhibitor, indomethacin, blocked PGE 2 synthesis, but did not further enhance IL-1 production or prevent suppressed IL-2 and IFN-γ production that was induced by live and killed B. abortus. These results suggest that B. abortus-induced suppression of IL-2 and IFN-γ production did not appear to be mediated by the suppressive prostaglandin, PGE 2, or other cyclo-oxygenase metabolites.
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