Abstract
Introduction: Ureteral obstruction by stones is one of the most common urological problems. Objectives: This study aimed to investigate the in vitro effects of hydroalcoholic extract of Peganum harmala L. on the contraction of the human ureter. Materials and Methods: In this study, 28 samples of human ureter tissue were studied. Six tissue samples were examined for the evaluation of P. harmala extract at concentrations of 1, 2, and 4 mg/mL. Moreover, five tissue samples were examined for checking NaCl solution since, six pieces of tissue for the examination of prazosin 10-8M solution. Results: There was a significant difference between the second contraction of P. harmala group with concentration of 4 mg/mL and NaCl group (P<0.001). Additionally, a significant difference between the prazosin and P. harmala groups with a concentration of 4 mg/mL (P=0.048) was observed. There is a marginal difference between the secondary contractions in two groups. A significant decrease in secondary contraction (15 minutes after adding the solution) was observed between the prazosin group and the P. harmala group at a concentration of 1 mg/mL (P<0.001). Moreover, the secondary contraction of the prazosin group showed a significant decrease compared with the NaCl group (P<0.001). Conclusion: Administration of P. harmala extract can be useful in reducing urinary human ureteric contractions while the best effect was achieved at 4 mg/mL of P. harmala extract.
Highlights
Ureteral obstruction by stones is one of the most common urological problems
Renal colic is one of the most commonly referred cases of emergency ward seen among the people aged 30 to 40 years with prevalence of 3 in 1000 every year, which is usually described as a severe pain in the flanks that is spread to the inguinal region and is associated with nausea and vomiting in 50% of people
Most of the causes of renal colic are due to the presence of upper urinary tract stones and urinary tract obstruction, and about 80% of the urinary tract stones are of calcium oxalate type [2]
Summary
Ureteral obstruction by stones is one of the most common urological problems. Objectives: This study aimed to investigate the in vitro effects of hydroalcoholic extract of Peganum harmala L. on the contraction of the human ureter. Results: There was a significant difference between the second contraction of P. harmala group with concentration of 4 mg/mL and NaCl group (P
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